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Actual: naltrexone plus active gabapentin (N=50), naltrexone plus placebo gabapentin (N=50), or placebo naltrexone and placebo gabapentin (N=50), using a double dummy placebo-controlled medication design. Naltrexone or its matching placebo was given as 25 mg for 2 days and then 50 mg/day for up to 16 weeks. Gabapentin (300-mg cap-
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Gabapentin also had preliminary efficacy as an add-on to naltrexone; in a trial of 150 alcohol-dependent subjects randomized to naltrexone (50 mg/day, n = 50) alone, naltrexone and gabapentin (up to 1,200 mg/day, n = 50) or double placebo (n = 50), the combined naltrexone/gabapentin group delayed the time to first HDD and decreased the number

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