Are platinum drugs renally cleared

In patients with impaired renal function, renal clearance and total body clearance of platinum are reduced. In patients undergoing hemodialysis, t values for total and ultrafilterable platinum are increased compared with values in individuals with normal renal function. Stability Storage Parenteral Injection Concentrate

Platinum analogues Tyrosine kinase inhibitors Vinca alkaloids Cardiovascular Diabetic drugs Pituitary hormones Renal preparations Sex hormones

The effects of many drugs are altered in renal impairment, particularly when a drug is renally cleared. Drug doses should be altered based on the predicted reduction in the

Intact cisplatin accounts for the majority of platinum excreted in the urine within one hour of administration. Renally excreted drugs. Literature data

The renal clearance of free (ultrafilterable) platinum also exceeds the glomerular filtration rate indicating that cisplatin or other platinum-containing

The first drug is usually a platinum product platinum product platinum is a metal and is an important ingredient in many anti-cancer drugs, either cisplatin

platinum containing compounds. Myelosuppression as a result of carboplatin treatment is closely related to the renal clearance of the drug.

weight metabolites as well as unchanged drug may have contributed to higher ultrafilterable platinum levels, but reduced renal clearance was consistent with

No significant relationships exist between the renal clearance of either free platinum or cisplatin and creatinine clearance. Although small amounts of platinum are present in the bile and large intestine after administration of cisplatin, the fecal excretion of platinum appears to be insignificant.