Max dose of losartan in 24 hours

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Actual: Patients with Marfan s syndrome were randomized to receive either losartan or atenolol. Losartan was administered at a maximum dose of 1.4 mg/kg/day (max 100 mg). Atenolol was administered at a maximum dose of 4 mg/kg/day (max 250 mg), with a goal of 20% decrease in mean heart rate by 24-hour recording.
4.5 rating 2025-04-27
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Comparison was made between 24 h BP-lowering effect of losartan mg and other ARBs at 50% max dose and the max dose, respectively. Sixty-two studies

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Losartan is approximately 33% orally bioavailable. 1,3,4 Losartan has a T max of 1 hour and the active metabolite has a T max of 3-4 hours. 1,3,4 Taking losartan with food decreases the C max but does only results in a 10% decrease in the AUC of losartan and its active metabolite. 1,3,4 A mg oral dose of losartan leads to a C max of 200

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