Bactrim hyperkalemia mechanism 📣 @bactrim_hyperkalemia

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The mechanism of Bactrim induced hyperkalemia is via Trimethoprim inhibition of the sodium channel located on the luminal surface of the principal cells, independent of aldosterone blockade. ( Same site of action of amiloride, triameterene and pentamidine).

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by DB Mount Cited by 40Both TMP/SMX (Bactrim) and pentamidine were reported to cause hyperkalemia mechanism of trimethoprim-induced hyperkalemia. Ann Intern Med 2024; 16

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The increase in creatinine associated with TMP is mild: 10% and reversible with drug discontinuation. The mechanism of Bactrim induced hyperkalemia is via Trimethoprim inhibition of the sodium channel located on the luminal surface of the principal cells, independent of aldosterone blockade.

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In addition to an elevated creatinine, Bactrim is also associated with hyperkalemia. The mechanism is felt to be a decreased aldosterone-

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Medscape - Indication-specific dosing for Bactrim, Bactrim DS, Septra, Septra Treatment with recommended doses may cause hyperkalemia when trimethoprim is

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