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Author: Admin | 2025-04-28
Stomach to make digestive acid in response to a meal. A Proton Pump Inhibitor blocks the pump so reducing acid production and reducing the level of acid in the stomach. As there is less acid, the symptoms of acid reflux and heartburn are reduced. Why are there so many different PPIs? The class of PPI medication was discovered in the 1970s, and omeprazole was the first one licensed in the UK. It was developed by AstraZeneca and sold as the brand 'Losec'. Other drug companies also developed their own PPI (e.g. esomeprazole and pantoprazole) by altering the chemical structures slightly. Most PPIs in the UK are now out of patent and so generic versions are also available alongside the branded originals. Research has shown that despite slight differences in the chemical structures all PPIs have very similar effects. Acid reflux treatment Which PPI should I use? Dr Fox offers a range of PPIs, as either capsules or tablets. They are all effective at treating symptoms of acid reflux/GORD/heartburn. It is best to take the lowest dose for the least amount of time. Losec/omeprazole 10mg capsules are the lowest dose to take once or twice a day. Nexium/esomeprazole and pantoprazole are stronger tablets (20mg) for once daily use. More people report side effects with lansoprazole and rabeprazole. Pantoprazole may be better for some people as there are fewer interactions with other medications and people report the fewest side effects with pantoprazole. Comparing PPIs Brand name Equivalent standard dose Equivalent low dose
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