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Author: Admin | 2025-04-28
Package insert / product labelGeneric name: hydrocodone bitartrate and aspirinDosage form: tabletDrug class: Narcotic analgesic combinations Hydrocodone and Aspirin Description Hydrocodone Bitartrate and Aspirin Tablets are immediate-release tablets for oral administration only. Each Hydrocodone Bitartrate and Aspirin Tablet, 5 mg/500 mg contains: Hydrocodone Bitartrate ……………….. 5 mg Aspirin ……………………………..... 500 mg Hydrocodone Bitartrate is an opioid agonist and occurs as fine, white crystals or as a crystalline powder. It is affected by light. It is soluble in water, slightly soluble in alcohol, and insoluble in ether and chloroform. The chemical name is: 4,5α-epoxy-3-methoxy-17-methylmorphinan-6-one tartrate (1:1) hydrate (2:5). It has the following structural formula: Aspirin, acetylsalicylic acid, is a nonsteroidal anti-inflammatory drug which is an odorless white, needle-like crystalline or powdery substance. The aspirin component is 2-(acetyloxy)-, Benzoic acid. When exposed to moisture, aspirin hydrolyzes into salicylic and acetic acids, and gives off a vinegary-odor. It is highly lipid soluble and slightly soluble in water; freely soluble in alcohol; soluble in chloroform and in ether; sparingly soluble in absolute ether. Its structure is as follows: In addition, each tablet contains the following inactive ingredients: Microcrystalline Cellulose, Anhydrous Lactose, Corn Starch, Hypromellose, Crospovidone, Stearic Acid, Talc, Colloidal Silicon Dioxide. Hydrocodone and Aspirin - Clinical Pharmacology Mechanism of Action Hydrocodone is full opioid agonist with relative selectivity for the mu-opioid (μ) receptor, although it can interact with other opioid receptors at higher doses. The principal therapeutic action of hydrocodone is analgesia. Like all full opioid agonists, there is no ceiling effect for analgesia with hydrocodone. Clinically, dosage is titrated to provide adequate analgesia and may be limited by adverse reactions, including respiratory and CNS depression. The precise mechanism of the analgesic action is unknown. However, specific CNS opioid receptors for endogenous compounds with opioid-like activity have been identified throughout the brain and spinal cord and are thought to play a role in the analgesic effects of this drug. Aspirin is a nonsteroidal anti-inflammatory drug. Aspirin (acetylsalicylic acid) is a more potent inhibitor of both prostaglandin synthesis and platelet aggregation than other salicylic acid derivatives. The differences in activity between aspirin and salicylic acid
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