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Author: Admin | 2025-04-28
Explore a selection of our essential drug information below, or:DescriptionA medication used to treat anxiety disorders and certain types of allergic skin conditions.DescriptionA medication used to treat anxiety disorders and certain types of allergic skin conditions.DrugBank IDDB00557TypeSmall MoleculeUS ApprovedYESOther ApprovedYESTherapeutic CategoriesHistamine Antagonists Miscellaneous Anxiolytics Sedatives and Hypnotics Mechanism of ActionHistamine H1 receptorInverse agonistSummaryHydroxyzine is an antihistamine used to treat anxiety and tension associated with psychoneuroses, as well as allergic conditions such as pruritus and chronic urticaria.Brand NamesAtarax, VistarilGeneric NameHydroxyzineDrugBank Accession NumberDB00557BackgroundHydroxyzine is a first-generation histamine H1-receptor antagonist of the dephenylmethane and piperazine classes that exhibits sedative, anxiolytic, and antiemetic properties.2,12 It was first developed in 1955,10 and has since remained a relatively common treatment for allergic conditions such as pruritus, urticaria, dermatoses, and histamine-mediated pruritus.18 The active metabolite of hydroxyzine, cetirizine, is also available as an active ingredient in allergic medications, and is responsible for much of its hydroxyzine's antihistaminic effect.13 Hydroxyzine is also used for generalized anxiety disorder, tension caused by psychoneurosis, and other conditions with manifestations of anxiety.18TypeSmall MoleculeGroupsApprovedStructureWeightAverage: 374.904 Monoisotopic: 374.176105825 Chemical FormulaC21H27ClN2O2SynonymsHidroxizinaHychotineHydroksyzynyHydroxineHydroxizineHydroxizinumHydroxycineHydroxyzinHydroxyzineHydroxyzinumIdrossizinaExternal IDs U.C.B-4492IndicationHydroxyzine is indicated for the symptomatic relief of anxiety and tension associated with psychoneuroses, and as an adjunct in organic disease states in which anxiety is manifested.18 It is also indicated in the treatment of histamine-mediated pruritus and pruritus due to allergic conditions such as chronic urticaria.18Canadian labeling states that hydroxyzine is also indicated in adults and children as a premedication prior to medical procedures, such as dental surgery.15 It is also used
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