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Author: Admin | 2025-04-28
Trial, but we have enrolled a few patients in it.**Editor’s note: The trial concluded in October 2009. As of February 2011, the findings had not yet been published.It will be interesting to see what happens, given that the other large alpha blocker studies have been negative.That’s true. But I should say that I still prescribe alfuzosin even though the placebo response rate was so high. After all, what have you got to lose? These men are in pain, and they don’t have many other options at the moment.Are researchers studying any other drugs that might ease prostatitis symptoms?Yes. There’s the pregabalin (Lyrica) trial. Pregabalin is used to treat fibromyalgia.People with fibromyalgia experience pain and stiffness in tendons, ligaments, and muscles, perhaps because of overly active nerves. What does that have to do with prostatitis?Many experts hypothesize that severe, abnormal tension and overly active nerves in the muscles of the pelvic floor [see Figure 2] could explain the pain, discomfort, and urinary problems associated with prostatitis. Given that pain and muscle stiffness are symptoms of both conditions, and that pregabalin is effective in treating fibromyalgia, it seemed worth trying in men with prostatitis.Tell us about the trial. Any encouraging findings?Like the other trials I’ve mentioned, it was a randomized, double-blind, placebo-controlled trial. We randomly assigned 324 men with pelvic pain for at least three of the previous six months to receive either pregabalin or a placebo daily for six weeks. The dose started at 150 mg, increased to 300 mg after
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